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Its structure was determined to be α-isomaltoside of Vanillyl alcohol, indicating that Vanillyl alcohol glucoside is a product of the first transglucosylation reaction and a substrate for second, so the whole reaction mechanism was proposed. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages. [1]. It was demonstrated that this reaction is very efficient (selectivity factor is 149) and occurred by a ping-pong mechanism with inhibition by glucose acceptor. Sign up today! Gastrodia elata Blume (GE) has long been used in oriental countries as a traditional herbal medicine to relieve symptoms associated with neurological ailments such as vertigo, general paralysis and epilepsy. Contusion injury significantly elevated the level of H2O2 in skeletal muscles and Achilles tendons. CAS No. We found that Vanillyl alcohol effectively inhibited the cytotoxicity and improved cell viability in MPP+-induced MN9D dopaminergic cells. CONCLUSIONS:It was demonstrated that the rate of isomaltoside synthesis is two orders of magnitude smaller than glucoside synthesis, and that maltase has interestingly high K(m) value to maltose when Vanillyl alcohol glucoside is second transglucosylation substrate. All of the co-solvents are provided by MCE. Vanillyl alcohol (VA) attenuates the elevation of reactive oxygen species (ROS) levels, decreases in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. METHODS AND RESULTS:A large amount of hydrogen peroxide (H2O2) are known to be generated during tissue damages such as mechanical injury and therefore H2O2 holds great potential as a diagnostic and therapeutic marker for mechanical injuries in the musculoskeletal system. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages. Recommendation for para-vanillyl alcohol usage levels up to: 8.0000 % in the fragrance concentrate. Pictogram: Signal Word: Warning: Hazard Statements : H315 : Causes skin irritation. In this study, we have investigated the effects of GE extracts and its major bioactive components on 1-methyl-4-phenylpyridinium (MPP+)-treated MN9D dopaminergic cells, a classic in vitro model for Parkinson's disease (PD). Fragment Libraries Drug-fragment Library Featured Fragment Library High Solubility Fragment Library Custom Compound Library. H O HO H 3CO 1. Based on 1 publication(s) in Google Scholar. Establishing an Artificial Pathway for De Novo Biosynthesis of Vanillyl Alcohol in Escherichia coli. Synonyms: 4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol, 4-Hydroxy-3-methoxybenzenemethanol. NaBH 4, NaOH 2. Subscribe above to receive our eNews, featuring scientific research, new products, and exclusive promotions. Vanillyl alcohol attenuated the elevation of reactive oxygen species (ROS) levels, decreased in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. Gastrodia elata Blume (GE) has long been used in oriental countries as a traditional herbal medicine to relieve symptoms associated with neurological ailments such as vertigo, general paralysis and epilepsy. vanillin, 1, and sodium borohydride, and the product, vanillyl alcohol, 2. Vanillyl alcohol glucoside is very attractive molecule due to its very powerful physiological activity. DMSO : 125 mg/mL (810.85 mM; Need ultrasonic), InChI=1S/C8H10O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,9-10H,5H2,1H3. please Contact Us For research use only. It was demonstrated that this reaction is very efficient (selectivity factor is 149) and occurred by a ping-pong mechanism with inhibition by glucose acceptor. These results indicate that Vanillyl alcohol protected dopaminergic MN9D cells against MPP+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process and is therefore a potential candidate for treatment of neurodegenerative diseases such as Parkinson's disease. We do not sell to patients. * Required Fields. Thanks, your subscription has been confirmed. Products are chemical reagents for research use only and are not intended for human use. TCI uses cookies to personalize and improve your user experience. for more assistance. For research use only. Sorry, but the email address you supplied was invalid. In this article, a detailed kinetic study of transglucosylation of Vanillyl alcohol was performed. Vanillyl alcohol can effectively inhibit the cytotoxicity and improved cell viability in 1-methyl-4-phenylpyridinium (MPP+)-induced MN9D dopaminergic cells, it also can attenuate the elevation of reactive oxygen species (ROS) levels, decrease in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol), derived from vanillin, is a phenolic alcohol and is used as a flavoring agent in foods and beverages. You can change or update your cookiesettings at any time. *Stock available in Belgium will be delivered in 1 to 3 days Its structure was determined to be α-isomaltoside of Vanillyl alcohol, indicating that Vanillyl alcohol glucoside is a product of the first transglucosylation reaction and a substrate for second, so the whole reaction mechanism was proposed. We're doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations.

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